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I'm look up chica that like Ecstasy and orange juice

This content has not been reviewed within the past year and may not represent WebMD's most up-to-date information. InDavid G. Bailey, PhD, and colleagues found that grapefruit juice increased blood concentrations of the blood pressure drug Plendil to possibly dangerous levels.


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A few years ago, a friend and I decided to drop acidand she went to the grocery store to stock up on orange juice beforehand.

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It is well known that intake of grapefruit juice affects the pharmacokinetics of various kinds of drugs. It has been reported Ecstasy and orange juice other citrus juices also interact with certain drugs. To re-evaluate citrus juice-drug interactions based on currently available evidence, a literature search was conducted for new and updated information since the grapefruit juice-drug interaction was last reviewed in The effects of grapefruit juice ingestion on the pharmacokinetics of orally administered drugs have been reported for 40 drugs since the reviews published in Increases in either area under the concentration-time curve AUC or maximum plasma concentration C max were found with 34 of these, the major mechanism being considered to be inactivation of intestinal cytochrome P 3A4, a so-called mechanism-based inhibition.

Although recent reports point to the inhibitory effects of grapefruit juice on the function of P-glycoprotein, which transports substrates from enterocytes back into the lumen, the contribution to the bioavailability of drugs that are substrates of P-glycoprotein has not been established yet. Dramatic decreases in AUC and C max for two drugs in association with grapefruit juice ingestion has been reported and, in these cases, inhibitory effects on organic anion transporting polypeptide, which mediates absorption from the intestinal lumen to enterocytes, might be involved. Other citrus juices such as Seville sour orange juice and commonly ingested varieties of orange juice also showed ificant effects on the AUC and C max of some drugs.

Although the situation is complex and uncertainties remain, we recommend that patients avoid citrus juice intake while taking medications and that healthcare providers advise against citrus juice intake in this setting until any interactions with subject drugs can be clarified in clinical studies. Please enable it to take advantage of the complete set of features!

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Fruit juices block common drugs

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Young adult ecstasy users’ enhancement of the effects of their ecstasy use

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RSS Link Copy. Full text links Cite Display options Display options. Abstract It is well known that intake of grapefruit juice affects the pharmacokinetics of various kinds of drugs.

Similar articles 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Edwards DJ, et al. Clin Pharmacol Ther. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P 3A4 activity: comparison with grapefruit juice. Bailey DG, et al.

Effects of grapefruit and Seville orange juices on the pharmacokinetic properties of colchicine in healthy subjects. Wason S, et al. Clin Ther. Epub Aug Medicinal importance of grapefruit juice and its interaction with various drugs. Kiani J, Imam SZ. Kiani J, et al.

Undesirable effects of citrus juice on the pharmacokinetics of drugs: focus on recent studies

Nutr J. Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance. Fuhr U. Drug Saf. PMID: Review. See all similar articles. Sridharan K, Sivaramakrishnan G. Sridharan K, et al. Eur J Drug Metab Pharmacokinet. Grapefruit juice improves glucose intolerance in streptozotocin-induced diabetes by suppressing hepatic gluconeogenesis. Hayanga JA, et al.

Eur J Nutr. Epub Mar PMID: Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.

Won CS, et al. Pharmacol Ther. Epub Aug 4. Serum concentrations and clinical effects of atorvastatin in patients taking grapefruit juice daily.

Reddy P, et al. Br J Clin Pharmacol. Different influences on tacrolimus pharmacokinetics by coadministrations of zhi ke and zhi shi in rats. Lin SP, et al. Evid Based Complement Alternat Med. Epub Jan See all "Cited by" articles. References Eur J Clin Pharmacol.

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